雷公藤多苷片聯(lián)合地氯雷他定治療慢性特發(fā)性蕁麻疹的臨床療效Meta分析

　　[摘要] 目的 采用Meta分析系統(tǒng)評價雷公藤多苷片聯(lián)合地氯雷他定治療慢性特發(fā)性蕁麻疹的臨床療效。方法 通過檢索CNKI、WANFANG DATA、VIP、CBM disc及Pubmed數(shù)據(jù)庫，收集雷公藤多苷片聯(lián)合地氯雷他定治療慢性特發(fā)性蕁麻疹的隨機(jī)對照試驗，采用RevMan 5.3軟件進(jìn)行Meta分析。結(jié)果 共納入文獻(xiàn)8篇，患者累計945例。Meta分析結(jié)果顯示，雷公藤多苷片聯(lián)合地氯雷他定可顯著提高兩藥對CIU患者的總有效人數(shù)并顯著降低復(fù)發(fā)人數(shù)，且不良反應(yīng)發(fā)生人數(shù)未明顯增高。結(jié)論 雷公藤多苷片聯(lián)合地氯雷他定治療慢性特發(fā)性蕁麻疹的療效確切。
　　[關(guān)鍵詞] 雷公藤多苷；地氯雷他定；利巴韋林；慢性特發(fā)性蕁麻疹；Meta分析
　　[中圖分類號] R758.24 [文獻(xiàn)標(biāo)識碼] A [文章編號] 1673-9701（2018）08-0019-04
　　Meta-analysis of the clinical efficacy of tripterygium wilfordii glycosides tablet combined with desloratadine in the treatment of chronic idiopathic urticaria
　　WANG Kun1，2 ZHANG Ping1 ZHAO Kuijun1 ZHONG Meng1 HUANG Feng3 XU Chang1
　　1.Department of Traditional Chinese Pharmacy， Beijing Friendship Hospital Affiliated to Capital Medical University， Beijing 100050， China； 2.Department of Pharmacy， Beijing Mentougou Maternal and Child Health Hospital， Beijing 102300， China； 3.Department of Acupuncture and Moxibustion， Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University， Beijing 100010， China
　　[Abstract] Objective To systematically evaluate the clinical efficacy of tripterygium wilfordii glycosides tablet combined with desloratadine in the treatment of chronic idiopathic urticaria by Meta-analysis. Methods Randomized controlled trials of tripterygium wilfordii glycosides tablet combined with desloratadine in the treatment of chronic idiopathic urticaria were collected by searching CNKI， WANFANG DATA， VIP， CBM disc and Pubmed databases. Meta-analysis was performed using RevMan 5.3 software. Results A total of 8 articles were included in the literature， and there were 945 patients. Meta-analysis showed that tripterygium wilfordii glycosides tablet combined with desloratadine could significantly improve the total effective number of two drugs in patients with CIU and significantly reduce the number of recurrence， and the number of adverse reactions did not significantly increased. Conclusion Tripterygium wilfordii glycosides tablet combined with desloratadine has curative effect in the treatment of chronic idiopathic urticaria.
　　[Key words] Tripterygium wilfordii glycosides tablet； Desloratadine； Ribavirin； Chronic idiopathic urticaria； Meta-analysis
　　慢性特發(fā)性蕁麻疹（Chronic idiopathic urticaria， CIU）是皮膚科臨床較為常見的變態(tài)反應(yīng)性疾病[1-2]，該病病程普遍較長，持續(xù)時間一般超過6周[3]；因病導(dǎo)致的睡眠中斷、疲勞、社會隔離與情緒干擾，對患者的正常生活產(chǎn)生了極大干擾[4-8]。該病給患者本人、家庭及醫(yī)療機(jī)構(gòu)造成巨大的精神壓力與經(jīng)濟(jì)損失，因而對此病的治療受到醫(yī)學(xué)界的廣泛關(guān)注[9]。但目前為止，尚無治療CIU的特異性方案，臨床常采用抗組胺藥物對癥治療，然而部分患者對此類藥物不敏感，且停藥后易復(fù)發(fā)，治療效果并不理想[10]。因此，探索治療CIU的新藥物與新方案是具有重大意義的工作。

相關(guān)熱詞搜索：蕁麻疹 療效 臨床 治療慢性 聯(lián)合