原發(fā)性肝癌患者介入治療預(yù)后影響因素分析
發(fā)布時(shí)間:2018-06-24 來(lái)源: 短文摘抄 點(diǎn)擊:
[摘要] 目的 探討原發(fā)性肝癌患者介入治療的預(yù)后影響因素。方法 方便選取2012年1月—2017年9月該院收治的60例原發(fā)性肝癌介入治療患者為例,依據(jù)術(shù)后3個(gè)月QOL-LC評(píng)分分為A組(高于或等于術(shù)前,30例)和B組(低于術(shù)前,30例),對(duì)比觀察兩組臨床資料,Logistic回歸分析影響原發(fā)性肝癌患者介入治療預(yù)后的影響因素。結(jié)果 A組年齡<40歲7例(23.33%),肝功能Child C級(jí)4例(13.33%),TNM分期III期4例(13.33%),浸潤(rùn)型生長(zhǎng)方式6例(20.00%),聯(lián)合用藥25例(83.33%),心態(tài)良好23例(76.67%),與對(duì)照組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 年齡、肝功能分級(jí)、TNM分期、門(mén)脈栓塞、聯(lián)合用藥化療、患者心態(tài)是影響原發(fā)性肝癌介入治療預(yù)后的獨(dú)立因素。
[關(guān)鍵詞] 原發(fā)性肝癌;介入治療;預(yù)后;影響因素
[中圖分類(lèi)號(hào)] R735 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-0742(2018)01(c)-0099-03
[Abstract] Objective This paper tries to investigate the prognostic factors of interventional therapy for primary liver cancer. Methods 60 cases of interventional treatment of primary liver cancer patients from January 2012 to September 2017 in this hospital were selected, according to QOL-LC grade of 3 months after operation, they were convenient divided into group A (greater than or equal to the preoperative, 30 cases) and group B (lower than preoperative, 30 cases), the clinical data of two groups were observed and compared, influencing factors of prognosis in patients with primary liver cancer treated by interventional therapy by Logistic regression were analyzed. Results 7 cases of group A, aged less than 40 years old(23.33%), 4 cases of liver function Child grade C (13.33%), 4 cases of TNM stage III (13.33%), Infiltrating type growth mode 6 cases(20.00%), 25 cases of combined medication (83.33%), good mentality of 23 cases(76.67%), with significant difference compared with control group(P<0.05). Conclusion Age, grading of liver function, TNM stage, mode of tumor growth, portal vein embolization, and patient’s attitude are independent factors influencing the prognosis of interventional therapy for primary liver cancer.
[Key words] Primary liver cancer; Interventional therapy; Prognosis; Influencing factors
原發(fā)性肝癌發(fā)生于肝細(xì)胞或肝內(nèi)膽管細(xì)胞,為我國(guó)消化系統(tǒng)常見(jiàn)惡性腫瘤,發(fā)病率僅次于胃癌和食管癌,居第三位[1]。肝癌介入治療指在影像設(shè)備引導(dǎo)下經(jīng)股動(dòng)脈插管將抗癌藥物或栓塞劑注入肝動(dòng)脈,其療效已經(jīng)得到肯定,是目前非開(kāi)腹手術(shù)治療肺癌的首選方法[2]。但是臨床實(shí)踐發(fā)現(xiàn),不同原發(fā)性肝癌患者介入治療的預(yù)后效果存在差異性,文章現(xiàn)以2012年1月—2017年9月該院60收治的例原發(fā)性肝癌介入治療患者為例進(jìn)行分析和探討,旨在為臨床制定個(gè)體化肝癌治療方案提供參考依據(jù),具體報(bào)道如下。
1 資料與方法
1.1 一般資料
方便選取該院收治的60例原發(fā)性肝癌患者為研究對(duì)象,全部患者均行介入治療。納入標(biāo)準(zhǔn):①病理檢查明確原發(fā)性肝癌診斷;②介入治療適應(yīng)證;③術(shù)后觀察隨訪3個(gè)月以上;④簽署知情同意書(shū)。排除標(biāo)準(zhǔn):①合并其他惡性腫瘤或轉(zhuǎn)移性肝癌;②肝臟介入治療禁忌證;③就往肝癌手術(shù)及放化療史;④臨床資料不完整或失真;⑤中途退出。入選病例中,男47例,女13例,年齡35~78歲,平均(56.1±9.3歲)。依據(jù)預(yù)后將入選病例分為A組(30例)和B組(30例),比較觀察兩組臨床資料。
1.2 方法
全部患者均擇期常規(guī)進(jìn)行肝癌介入治療。治療前及治療后3個(gè)月,分別以QOL-LC(肝癌患者生活質(zhì)量測(cè)定量表)評(píng)價(jià)患者預(yù)后。治療后QOL-LC評(píng)分高于或等于治療前為A組,治療后QOL-LC評(píng)分低于治療前為B組;仡櫺苑治鰞山M患者臨床資料,對(duì)患者性別、年齡、肝癌分期、臨床分型、腫瘤最長(zhǎng)直徑、介入次數(shù)、化療用藥種類(lèi)數(shù)、患者心態(tài)等可能影響肝癌介入預(yù)后的因素進(jìn)行統(tǒng)計(jì)分析。
相關(guān)熱詞搜索:預(yù)后 原發(fā)性 肝癌 患者 因素
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