自擬降壓方治療頑固性高血壓的臨床療效及對(duì)Hcy、AngⅡ的影響

　　摘要：目的 探討自擬降壓方治療頑固性高血壓的臨床療效。方法 將64例頑固性高血壓患者為研究對(duì)象，按隨機(jī)數(shù)字表法分為觀察組33例和對(duì)照組31例，對(duì)照組采用西醫(yī)規(guī)范治療，觀察組在此基礎(chǔ)上給予口服自擬降壓方聯(lián)合降壓方足浴治療，療程3月。結(jié)果 2組患者的收縮壓及舒張壓均出現(xiàn)了下降，差異有統(tǒng)計(jì)學(xué)意義（P<0.05），但下降程度及血壓達(dá)標(biāo)率，觀察組明顯優(yōu)于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。2組患者的AngⅡ平均較前下降，差異有統(tǒng)計(jì)學(xué)意義（P<0.05），但改善程度觀察組優(yōu)于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；2組患者的Hcy平均較前下降，觀察組治療前后比較，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；對(duì)照組治療前后比較，差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）。2組患者的SAS、SDS、SPIEGEL評(píng)分均出現(xiàn)改善，差異有統(tǒng)計(jì)學(xué)意義（P<0.05），但改善程度，觀察組明顯優(yōu)于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 自擬降壓方能改善焦慮、抑郁情緒，降低Hcy、AngⅡ的水平，達(dá)到控制高血壓，提高臨床療效。
　　關(guān)鍵詞：疏肝熄風(fēng)；頑固性高血壓；焦慮；抑郁
　　中圖分類(lèi)號(hào)：R544.1 文獻(xiàn)標(biāo)志碼：B 文章編號(hào)：1007-2349（2018）02-0033-03
　　Clinical Curative Effect 0f Self-made Antihypertensive Prescription on Treatment
　　of Refractory Hypertension and its Effect on Hcy and AngⅡ
　　HE Zhi-liang， GAO Jiang-bao， SUN Wu， CHEN Guan-zi
　�。≒anyu District Hospital of Traditional Chinese Medicine， Guangzhou， 511400， China）
　　【Abstract】Objective： To study the clinical effect of self-made antihypertensive prescription on the treatment of refractory hypertension. Methods： 64 patients were divided into an observation group （n=33） and a control group （n=31） according to random number table. The control group was given western medicine of standard treatment. The observation group， on the basis of western medicine of the control group， was given oral self-made antihypertensive decoction combined with foot bath treatment. The course was 3 months. Results： The systolic and diastolic blood pressures of the two groups decreased and the difference was significant （P<0.05）， but the degree of decline and blood pressure compliance rate of the observation group were significantly higher than those of the control group （P<0.05）. The mean AngⅡof the patients in the two groups was lower than before and the difference was statistically significant（P<0.05）， but the degree of improvement in the observation group was superior to that in the control group， with a significant difference （P<0.05）. The mean Hcy of the two groups decreased than before. The comparison of pre-and-post treatment of the observation group showed the difference was statistically significant （P<0.05）， The comparison of pre-and-post treatment of the control group showed the difference was not statistically significant （P>0.05）. The scores of SAS， SDS and SPIEGEL in the two groups improved， and the difference was statistically significant （P<0.05）， but the improvement in the observation group was better than that in the control group and the difference was statistically significant （P<0.05）. Conclusion： Self-made hypotension prescription can improve anxiety and depression， reduce the levels of Hcy and AngⅡand achieve the goal of controlling hypertension and improving clinical effectiveness.

相關(guān)熱詞搜索：頑固性 降壓 高血壓 療效 臨床