右美托咪定輔舒芬太尼用于全麻患者的術(shù)后鎮(zhèn)痛

　　【摘要】 目的：探討和分析右美托咪定輔舒芬太尼用于全麻患者的術(shù)后鎮(zhèn)痛效果。方法：選取筆者所在醫(yī)院280例全麻患者作為本次研究對(duì)象，按照麻醉方式的不同將其分成對(duì)照組和治療組，每組140例，對(duì)照組患者采用生理鹽水聯(lián)合舒芬太尼進(jìn)行麻醉，治療組采用右美托咪定聯(lián)合舒芬太尼進(jìn)行麻醉，比較兩組患者術(shù)后8、24、48 h內(nèi)的鎮(zhèn)痛效果評(píng)分、血流動(dòng)力學(xué)指標(biāo)及不良反應(yīng)發(fā)生率。結(jié)果：治療組患者術(shù)后8 h的鎮(zhèn)痛評(píng)分明顯低于對(duì)照組，治療組患者術(shù)后的血流動(dòng)力學(xué)指標(biāo)（心率、平均動(dòng)脈壓、呼吸頻率、脈搏氧飽和度等）穩(wěn)定性高于對(duì)照組，治療組患者的不良反應(yīng)發(fā)生率明顯低于對(duì)照組，兩組對(duì)比差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論：對(duì)行全麻手術(shù)患者采用右美托咪定聯(lián)合舒芬太尼進(jìn)行麻醉，不僅能有效緩解患者手術(shù)的疼痛感，同時(shí)還能使患者機(jī)體的血流動(dòng)力學(xué)指標(biāo)維持在正常水平，麻醉效果安全可靠。
　　【關(guān)鍵詞】 右美托咪定； 舒芬太尼； 鎮(zhèn)痛效果
　　doi：10.14033/j.cnki.cfmr.2018.5.009 文獻(xiàn)標(biāo)識(shí)碼 B 文章編號(hào) 1674-6805（2018）05-0018-03
　　【Abstract】 Objective：To investigate and analyze the postoperative analgesic effect of dexmedetomidine and Sufentanil in general anesthesia patients.Method：280 patients with general anesthesia were selected as the subjects.According to the different methods of anesthesia，they were divided into the control group and the treatment group.There were 140 patients in each group.The patients in the control group were treated with Physiological Saline combined with Sufentanil for anesthesia and treatment.The treatment group were treated by Dexmedetomidine combined with Sufentanil.The analgesic effect score after 8 h，24 h
　　and 48 h，hemodynamics index after 8 h and 48 h and the incidence of adverse reactions were compared between the two groups postoperatively.Result：The analgesic score of the treatment group after 8 h was significantly lower than that of the control group.The hemodynamic parameters（heart rate，blood pressure，respiratory rate，pulse oxygen saturation，etc.） were more steady in the treatment group than in the control group（P<0.05）.The incidence of adverse reactions was significantly lower than that of the control group（P<0.05）.Conclusion：The combination of Dexmedetomidine and Sufentanil in the patients undergoing general anesthesia can not only relieve the pain of the patients’ operation，but also keep the hemodynamics of the patients in the normal level.The effect is safe and reliable.
　　【Key words】 Dexmedetomidine； Sufentanil； Analgesic effect
　　First-author’s address：The First People’s Hospital of Nankang District Ganzhou City，Ganzhou 341400，China
　　患者在行手術(shù)治療期間，手術(shù)的疼痛不僅會(huì)影響其對(duì)手術(shù)治療的配合度，同時(shí)還會(huì)導(dǎo)致患者機(jī)體出現(xiàn)疼痛應(yīng)激反應(yīng)，并引發(fā)一系列的并發(fā)癥發(fā)生[1]。為緩解患者手術(shù)治療的痛苦，臨床現(xiàn)多采用局部麻醉和全麻的方式輔助手術(shù)治療，麻醉藥物雖能有效緩解患者機(jī)體的疼痛，但其使用不當(dāng)或過(guò)量也會(huì)對(duì)患者機(jī)體產(chǎn)生較大的毒副作用，為此選擇麻醉藥物時(shí)需慎重[2-4]。右美托咪定和舒芬太尼是臨床常用的麻醉藥物，兩種藥劑均具有良好的鎮(zhèn)痛和鎮(zhèn)靜效果，本文主要探究了右美托咪定輔舒芬太尼用于全麻患者的術(shù)后鎮(zhèn)痛效果，現(xiàn)報(bào)告如下。
　　1 資料與方法
　　1.1 一般資料
　　選取筆者所在醫(yī)院2016年3月-2017年3月收治的280例行全麻手術(shù)治療的患者作為本次研究對(duì)象，患者均無(wú)相關(guān)禁忌，在手術(shù)前患者均簽署知情同意書(shū)。按照麻醉方式的不同將其分成對(duì)照組和治療組，每組140例，對(duì)照組中男74例，女66例，患者年齡36～69歲，平均（42.6±1.8）歲；對(duì)照組中男81例，女59例，患者年齡35～71歲，平為（43.5±1.7）歲，兩組患者年齡、性別等比較，差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）。

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