乳腺癌根治術(shù)后不同放療技術(shù)的應(yīng)用與劑量分析

　　摘 要 目的：分析乳腺癌根治術(shù)后不同放療技術(shù)的應(yīng)用與劑量。方法：選取2012年2月至2016年4年收治的乳腺癌根治術(shù)后患者30例，隨機(jī)分為對(duì)照組與觀察組各15例。對(duì)照組采用普通放療計(jì)劃，觀察組采用三維適形放療，均根據(jù)處方劑量50 Gy進(jìn)行放療。觀察比較兩組計(jì)劃靶區(qū)（PTV）劑量參數(shù)、分次治療時(shí)間以及近期不良反應(yīng)。結(jié)果：觀察組PTV各劑量參數(shù)顯著低于對(duì)照組（P<0.05），分次治療時(shí)間明顯短于對(duì)照組（P<0.05），近期不良反應(yīng)發(fā)生率為6.67%（1/15），低于對(duì)照組的20.0%（3/15，P<0.05）。結(jié)論：乳腺癌根治術(shù)后采用三維適形放療的效果更為顯著，即靶區(qū)劑量覆蓋均勻性顯著較高，且能顯著減少危急器官的平均劑量以及高劑量區(qū)體積，同時(shí)還能減少各種近期不良反應(yīng)，值得推廣應(yīng)用。
　　關(guān)鍵詞 乳腺癌；放射治療；劑量
　　中圖分類號(hào)：R737.9 文獻(xiàn)標(biāo)志碼：A 文章編號(hào)：1006-1533（2018）04-0019-02
　　Application and dose analysis of different radiotherapy techniques after radical mastectomy for the breast cancer
　　ZHU Tong
　�。∣ncology Department of Central People’s Hospital of Jian， Jian 343000， Jiangxi Province， China）
　　ABSTRACT Objective： To analyze the application and dosage of different radiotherapy techniques after radical mastectomy. Methods： Thirty cases of breast cancer after radical mastectomy in 4 years from February 2012 to February 2016 were selected and randomly divided into a control group and an observation group with 15 cases each. The control group was treated with a general radiotherapy plan， and three-dimensional conformal radiotherapy was used in the observation group and the radiotherapy was performed on the basis of prescription agent 50 Gy. The dose parameters， fractional treatment time and shortterm adverse reactions of planned target area （PTV） in two groups were observed and compared. Results： The dose of PTV in the observation group was significantly lower than that in the control group（P<0.05）. The treatment time of the observation group was significantly shorter than that of the control group（P<0.05）. The incidence of recent adverse reactions was 6.67%（1/15）， which was lower than that of the control group 20%（3/15）（P<0.05）. Conclusion： The effect of Three-dimensional conformal radiotherapy is more significant after radical mastectomy. That is the dose coverage uniformity in the target area is significantly higher， and it can significantly reduce the average dose of critical organs and the volume of high dose area. At the same time， it can also reduce a variety of adverse reactions in the near future， which is worth popularizing.
　　KEY WORDS breast cancer； radiotherapy； dose
　　目前，針對(duì)乳腺浸潤(rùn)性導(dǎo)管癌，臨床綜合治療手段主要為放射治療，能有效減少患者的術(shù)后復(fù)發(fā)率和死亡率[1-2]。但在乳腺癌根治術(shù)后，患者容易出現(xiàn)各種不良反應(yīng)[3]。本文對(duì)乳腺癌根治術(shù)后不同放療技術(shù)的應(yīng)用與劑量進(jìn)行了研究與分析，現(xiàn)報(bào)道如下。
　　1 資料與方法
　　1.1 一般資料
　　選取2012年2月至2016年4年吉安市中心人民醫(yī)院腫瘤科收治的乳腺癌根治術(shù)后患者30例，采用計(jì)算機(jī)隨機(jī)分為對(duì)照組和觀察組各15例。對(duì)照組年齡25～60歲，平均（45.2±3.6）歲，觀察組年齡26～63歲，平均（46.3±2.7）歲。兩組基本資料差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）。

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