多巴胺聯(lián)合多巴酚丁胺治療慢性心力衰竭合并腎功能不全的效果觀察

　　[摘要]目的 探討多巴胺聯(lián)合多巴酚丁胺治療慢性心衰合并腎功能不全的效果。方法 選取2014年2月～2016年9月我院收治的60例慢性心衰合并腎功能不全患者作為研究對象，采用隨機分配方式將其分為觀察組和對照組，每組各30例。對照組患者采用常規(guī)藥物治療，觀察組患者采用多巴胺聯(lián)合多巴酚丁胺治療。比較兩組患者的治療效果、不良反應發(fā)生情況以及左室舒張末期內徑（LVEDD）、左室射血分數(shù)（LVEF）、血尿素氮（BUN）等心腎功能臨床指標。結果 觀察組患者的治療總有效率（93.33%）高于對照組（73.33%），差異有統(tǒng)計學意義（P<0.05）。治療前，兩組患者的心腎功能指標比較，差異無統(tǒng)計學意義（P>0.05）。治療前，兩組患者的心腎功能指標比較，差異無統(tǒng)計學意義（P>0.05）。治療后，兩組患者的LVEDD、BUN低于治療前，LVEF高于治療前，差異有統(tǒng)計學意義（P<0.05），且觀察組患者的LVEDD、BUN顯著低于對照組，LVEF指標顯著高于對照組，差異均有統(tǒng)計學意義（P<0.05）。觀察組患者的不良反應發(fā)生率（6.67%）低于對照組（26.67%），差異有統(tǒng)計學意義（P<0.05）。結論 多巴胺聯(lián)合多巴酚丁胺治療慢性心衰合并腎功能不全的臨床效果顯著，能夠降低不良反應發(fā)生率，有效改善患者的臨床癥狀，值得臨床推廣。
　　[關鍵詞]多巴胺；多巴酚丁胺；慢性心衰合并腎功能不全；臨床效果
　　[中圖分類號] R541.61 [文獻標識碼] A [文章編號] 1674-4721（2018）2（b）-0135-03
　　Effect of Dopamine combined with Dobutamine on chronic heart failure with renal insufficiency
　　ZHANG Qing
　　Department of Cardiology，Liaoyang Central Hospital，Liaoning Province，Liaoyang 111000，China
　　[Abstract]Objective To investigate the effect of Dopamine combined with Dobutamine in the treatment of chronic heart failure complicated with renal insufficiency.Methods A total of 60 patients with chronic heart failure complicated with renal insufficiency admitted in our hospital from February 2014 to September 2016 were selected as subjects，and they were divided into observation group and control group by random distribution，30 cases in each group.The control group was treated with conventional drugs.The observation group was treated with Dopamine and Dobutamine.The effects of treatment，adverse reactions and the left ventricular diastolic （LVEDD），left ventricular ejection fraction （LVEF） and blood urea nitrogen （BUN） of the two groups were compared.Results The total effective rate in the observation group （93.33%） was higher than that in the control group （73.33%），and the difference was statistically significant （P<0.05）.Before treatment，there was no statistically significant difference between the two groups of patients with heart and kidney function （P>0.05）.After treatment，the LVEDD and BUN were lower than before treatment in both groups，the LVEF was higher than before the treatment，and the differences were statistically significant （P<0.05）.The LVEDD and BUN of patients in the observation group were significantly lower than those in the control group，while the LVEF was significantly higher than that in the control group，and the differences were statistically significant （P<0.05）.The incidence of adverse reactions in the observation group （6.67%） was lower than that in the control group （26.67%），and the difference was statistically significant （P<0.05）.Conclusion The clinical effect of Dopamine combined with Dobutamine in the treatment of chronic heart failure complicated with renal insufficiency is significant，which can reduce the incidence of adverse reactions and effectively improve the clinical symptoms of patients，it is worthy of clinical promotion.

相關熱詞搜索：多巴胺 心力衰竭 不全 腎功能 合并