基于紋黨參鮮藥材的產(chǎn)地加工炮制一體化技術(shù)研究

　　摘要：目的 研究不同干燥過程對紋黨參飲片有效成分的影響，確定最佳的基于紋黨參鮮藥材的產(chǎn)地初加工與炮制一體化工藝。方法 對采收期的紋黨參鮮藥材分別采用3種加工炮制方法：①烘箱80 ℃烘至含水量為藥材原始含水量不同百分比（30%～100%）時，分別取出切片，50 ℃烘干，制得8個飲片樣品（XⅠYP1～8）。②鮮紋黨參直接在不同溫度（50～120 ℃）分別烘至含水量為藥材原始含水量的50%時，取出切片，50 ℃烘干，制得8個飲片樣品（XⅡYP1～8）。③紋黨參干藥材，悶潤，切片，自然晾干，制得傳統(tǒng)飲片。采用HPLC測定各樣品中黨參炔苷和蒼術(shù)內(nèi)酯Ⅲ，苯酚-硫酸法和比色法分別測定多糖及總黃酮含量，并同時測定醇浸出物、水浸出物含量。結(jié)果 飲片XⅠYP3的醇浸出物（55.36%）、水浸出物（54.91%）和蒼術(shù)內(nèi)酯Ⅲ（10.95 ?g/g）含量均高于其他飲片。結(jié)論 優(yōu)選的工藝為：80 ℃烘至含水量50%，切片，干燥。獲得的一體化加工工藝較傳統(tǒng)方法省時、省力。制得的飲片活性成分含量高。
　　關(guān)鍵詞：鮮紋黨參；產(chǎn)地加工；炮制；一體化
　　DOI：10.3969/j.issn.1005-5304.2017.01.018
　　中圖分類號：R282.4 文獻標識碼：A 文章編號：1005-5304（2017）01-0071-06
　　Study on Producing and Preparing Integration Process based on Fresh Codonopsis pilosula Nannf.var.modesta （Nannf.） L.T.Shen QIANG Si-si1，2， GAO Xia1， MA Yu-ling1， ZHENG Xiao-ping1， HU Fang-di1，3， LI Ying-dong3 （1. School of Pharmacy， Lanzhou University， Lanzhou 730000， China； 2. Third Affiliated Hospital of Beijing University of Chinese Medicine， Beijing 100029， China； 3. Gansu University of Chinese Medicine， Lanzhou 730000， China）
　　Abstract： Objective To study the effects of different drying processes on the effective constituents in Wen Codonopsis pilosula （WPP） Decoction Pieces； To develop the optimized producing and preparing integration process based on fresh WPP. Methods Fresh WPP in harvest period was prepared respectively as follows： ① Fresh WPP was dried to different percentage （30%–100%） of original moisture contents of crude drugs at 80 ℃ in oven， then sliced and dried at 50 ℃ to obtain eight decoction pieces of WPP （XⅠYP1–8）. ② The fresh WPP was baked to 50% of water content of crude drug under different temperatures （50–120 ℃）， respectively， then sliced and dried at 50 ℃ to obtain eight decoction pieces of WPP （XⅡYP1–8）. ③ Dried WPP was moistened， sliced and naturally dried， then were renamed as traditional decoction pieces. The contents of lobetyolin and atractylenolide Ⅲ was determined by HPLC. The phenol-sulfuric acid and colorimetric method were applied respectively to detect contents of polysaccharide and total flavonoids. The contents of aqueous and alcoholic extracts were determined simultaneously. Results The contents of alcoholic extracts （55.36%）， aqueous extracts （54.91%） and atractylenolide Ⅲ （10.95 ?g/g） in XⅠYP3 pieces were higher than other decoction pieces. Conclusion The optimized process was that fresh WPP was baked to water content of 50% at 80 ℃， then sliced and dried. Compared with conventional preparing methods，
　　基金項目：甘肅省科技支撐計劃-社會發(fā)展類（1504FKCA010）；甘肅中醫(yī)藥管理局科研課題（GZK-2014-13，GZK-2015-19）；蘭州市科技計劃項目（2013-4-75、2014-2-30）

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