生長(zhǎng)激素對(duì)重度宮腔黏連患者的治療效及對(duì)妊娠結(jié)局和炎性細(xì)胞因子的影響

　　[摘要] 目的 探討生長(zhǎng)激素對(duì)重度宮腔黏連患者的治療效果及對(duì)妊娠結(jié)局和炎性細(xì)胞因子水平的影響。 方法 選取2014年6月～2017年3月右江民族醫(yī)學(xué)院附屬醫(yī)院婦產(chǎn)科診治的66例重度宮腔黏連患者為研究對(duì)象，按照是否使用生長(zhǎng)激素將患者分為對(duì)照組（宮腔粘連分離術(shù)+雌激素治療）+觀察組（宮腔粘連分離術(shù)+雌激素+生長(zhǎng)激素干預(yù)），每組各33例。比較兩組患者的臨床治療效果和妊娠結(jié)局，應(yīng)用酶聯(lián)免疫吸附試驗(yàn)測(cè)定炎性細(xì)胞因子白細(xì)胞介素-6（IL-6）、白細(xì)胞介素-8（IL-8）和腫瘤壞死因子-α（TNF-α）的變化水平。 結(jié)果 觀察組患者的月經(jīng)改善率明顯高于對(duì)照組（χ2=4.232，P=0.039），且宮腔再黏連率也明顯低于對(duì)照組（χ2=3.995，P=0.046）；觀察組患者的試孕成功率明顯高于對(duì)照組（χ2=3.986，P=0.046），但兩組不良反應(yīng)發(fā)生率比較，差異無統(tǒng)計(jì)學(xué)意義（χ2=0.733， P=0.392）；觀察組患者的子宮內(nèi)膜厚度明顯高于對(duì)照組（P < 0.05），但兩組患者子宮內(nèi)膜容積、阻力指數(shù)和搏動(dòng)指數(shù)比較，差異無統(tǒng)計(jì)學(xué)意義（P > 0.05）。治療后觀察組患者的IL-6、IL-8和TNF-α水平均明顯低于對(duì)照組，差異均有統(tǒng)計(jì)學(xué)意義（P < 0.05）。 結(jié)論 生長(zhǎng)激素可顯著提高宮腔黏連患者的治療效果，改善妊娠結(jié)局，降低炎性細(xì)胞因子水平。
　　[關(guān)鍵詞] 生長(zhǎng)激素；重度宮腔黏連；細(xì)胞因子；妊娠結(jié)局
　　[中圖分類號(hào)] R711 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1673-7210（2018）02（c）-0084-04
　　Effect of growth hormone in the treatment of patients with severe intrauterine adhesions and its effect on the outcome of pregnancy and the level of inflammatory cytokines
　　YANG Li WU Huizhen GAN Haisi
　　Department of Obstetrics and Gynecology， Affiliated Hospital of Youjiang Medical University for Nationalities， Guangxi Zhuang Autonomous Region， Baise 533000，China
　　[Abstract] Objective To investigate the effect of growth hormone on the treatment of patients with severe intrauterine adhesions and its effect on the outcome of pregnancy and the level of inflammatory cytokines. Methods Sixty-six patients with severe intrauterine adhesions treated in Obstetrics and Gynecology of Affiliated Hospital of Youjiang Medical University for Nationalities from June 2014 to March 2017 were selected as study subjects， and all patients were divided into control group （intrauterine adhesions separation surgery + estrogen therapy） + observation group （intrauterine adhesions separation + estrogen + growth hormone intervention） according to whether usedgrowth hormone， each group had 33 cases. The clinical treatment effect and pregnancy outcomes were compared between two groups， the levels of inflammatory cytokines interleukin-6 （IL-6）， interleukin-8 （IL-8） and tumor necrosis factor-α （TNF-α） were measured by enzyme linked immunosorbent assay. Results The improvement rate of menstruation in the observation group was significantly higher than that in the control group （χ2=4.232， P=0.039）， and the intrauterine readhesion rate was also significantly lower than that in the control group （χ2=3.995， P=0.046）. The pregnancy success rate was significantly higher than that of the control group （χ2=3.986， P=0.046）， but there was no significant difference in the incidence of adverse reactions between the two groups （χ2=0.733， P=0.392）. The endometrial thickness of the observation group was significantly higher than that of the control group （P < 0.05）. However， there was no significant difference in endometrial volume， resistance index and pulsatility index between the two groups （P > 0.05）. In addition， the levels of IL-6， IL-8 and TNF-α in the observation group were significantly lower than those in the control group after the treatment （P < 0.05）. Conclusion Growth hormone can significantly improve the treatment of patients with intrauterine adhesions， improve pregnancy outcomes， reduce the level of inflammatory cytokines.

相關(guān)熱詞搜索：細(xì)胞因子 生長(zhǎng)激素 妊娠 患者 結(jié)局