Ⅱ型心腎綜合征患者不同腎功能分期的紅細(xì)胞參數(shù)比較

　　[摘要] 目的 比較Ⅱ型心腎綜合征患者的紅細(xì)胞參數(shù)，明確其與炎癥和貧血狀態(tài)的相關(guān)性。 方法 選擇2009年1月～2015年12月于廣安門(mén)醫(yī)院心內(nèi)科住院的Ⅱ型心腎綜合征患者209例，根據(jù)腎小球?yàn)V過(guò)率（GFR）分為慢性腎臟�。–KD）3期組（129例）、CKD4期組（59例）、CKD5期組（21例），單純慢性心力衰竭（CHF）患者88例為CHF組。另選擇健康者152例為健康組，檢測(cè)各組的紅細(xì)胞參數(shù)并統(tǒng)計(jì)比較。 結(jié)果 各組紅細(xì)胞（RBC）、血紅蛋白（Hb）、血細(xì)胞比容（HCT）比較：CKD3～5期組低于健康組，CKD4～5期組低于CHF組，CKD5期組低于CKD3期組，差異均有統(tǒng)計(jì)學(xué)意義（P < 0.01），CKD5期組與CKD4期組比較，差異無(wú)統(tǒng)計(jì)學(xué)意義（P > 0.05）。CHF組RBC、HCT低于健康組，差異有統(tǒng)計(jì)學(xué)意義（P < 0.05或P < 0.01）。各組RDW-CV比較：CHF組、CKD3～5期組高于健康組，CKD4期組高于CHF組，差異有統(tǒng)計(jì)學(xué)意義（P < 0.05或P < 0.01）。平均血紅蛋白濃度（MCHC）、紅細(xì)胞分布寬度變異系數(shù)（RDW-CV）與Ⅱ型心腎綜合征發(fā)生呈顯著正相關(guān)（P < 0.05）；RBC、Hb、HCT、平均紅細(xì)胞體積、平均血紅蛋白量與Ⅱ型心腎綜合征發(fā)生呈顯著負(fù)相關(guān)（P < 0.05）。 結(jié)論 Ⅱ型心腎綜合征患者炎癥和貧血狀態(tài)與紅細(xì)胞參數(shù)相關(guān)，并且可能隨心、腎功能降低而加重。
　　[關(guān)鍵詞] Ⅱ型心腎綜合征；紅細(xì)胞參數(shù)；貧血；炎癥
　　[中圖分類號(hào)] R556.3 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1673-7210（2018）02（c）-0163-04
　　[Abstract] Objective To investigate the levels of inflammation and anemia in patients of TypeⅡ cardio-renal syndrome. Methods Two hundred and nine cases of Type Ⅱ cardio-renal syndrome patients were divided into Chronic kidney disease CKD3 period group （129 cases）， CKD4 period group （59 cases） and CKD5 period group （21 cases）， 88 cases of chronic heart failure （CHF） patients as CHF group， eolled in Department of Cardiology， Guang′ anmen Hospital from January 2009 to December 2009， and a total of 152 healthy people as healthy group were selected. The levels of red blood cell parameters in each group were examined. Results The comparison of levels of red blood cell count （RBC）， hemoglobin （Hb）， hematocrit （HCT）： CKD3， CKD4， CKD5 groups were lower than healthy group， and CKD4， CKD5 groups were lower than CHF group， and CKD5 group was lower than CKD3 group， and the difference was significant （P < 0.01）.The levels of RBC and HCT in CHF group were lower than those of healthy group， and the difference was significant （P < 0.01 or P< 0.05）.The comparison of levels of red blood cell volume distribution width （RDW-CV）： CHF， CKD3， CKD4， CKD5 groups werehigherthan healthy group， and CKD4 group washigher than CHF group， and the difference was significant （P < 0.01 or P < 0.05）. Mean corpuscular hemoglobin concentration （MCHC）， RDW-CV were positively correlated with Type Ⅱ cardio-renal syndrome （P < 0.05）. RBC， Hb， HCT， mean corpuscular volume （MCV）， mean corpuscular hemoglobin （MCH） were negatively correlated with the Type Ⅱ cardio-renal syndrome （P < 0.05）. Conclusion The levels of inflammation and anemia in Type Ⅱ cardio-renal syndromepatientsare associated with red blood cell parameters， and may increase according to the reduction of cardiacfunction and renal function.

相關(guān)熱詞搜索：紅細(xì)胞 綜合征 腎功能 患者 參數(shù)