甘精胰島素聯(lián)合瑞格列奈治療2型糖尿病臨床療效觀察
發(fā)布時間:2018-06-23 來源: 散文精選 點擊:
[摘要] 目的 探討甘精胰島素聯(lián)合瑞格列奈治療2型糖尿病的治療效果。 方法 選擇我院2016年3月~2017年6月間收治的2型糖尿病患者72例作為研究對象,按照電腦隨機數(shù)分組的方案,將其隨機分為兩組,分別為對照組和實驗組,每組36例患者。對照組患者采用單純預混胰島素進行治療,而實驗組患者則應用甘精胰島素聯(lián)合瑞格列奈進行治療。對比兩組患者的治療效果,記錄兩組患者的空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血紅蛋白(HbA1c)的數(shù)值,分析治療效果。 結果 實驗結果顯示,實驗組患者的治療總有效率較對照組明顯更高,差異具有統(tǒng)計學意義(P<0.05)。兩組患者在治療完成后,各項指標數(shù)據(jù)均有所改善,但實驗組患者改善程度較對照組明顯更優(yōu),差異具有統(tǒng)計學意義(P<0.05)。 結論 應用甘精胰島素聯(lián)合瑞格列奈對2型糖尿病患者進行治療能夠有效提高患者的治療效果,緩解患者的臨床癥狀,控制患者的各項血糖指標水平,具有較好的治療效果,值得在臨床上推廣使用。
[關鍵詞] 甘精胰島素;瑞格列奈;2型糖尿病
[中圖分類號] R587.1 [文獻標識碼] B [文章編號] 1673-9701(2018)08-0042-03
Curative effect observation of treatment combining insulin glargine and repaglinide in patients with type-2 diabetes
WANG Yuanfang
Department of Internal Medicine, Zaozhuang Hospital of Zaozhuang Mining Group, Zaozhuang 277100, China
[Abstract] Objective To investigate the curative effect of treatment combining insulin glargine and repaglinide in patients with type-2 diabetes. Methods 72 patients with tyepe-2 diabetes in our hospital from March 2016 to June 2017 were selected and randomized into control group and study group according to grouping schemes generated through computer random number with 36 patients in each. Patients in control group were treated with pure premixed insulin while patients in study group were treated with insulin glargine and repaglinide. The curative effect of patients in two groups was compared. The levels of fasting plasma glucose(FPG), 2-hour postprandial plasma glucose(2hPG) and glycosylated hemoglobin(HbA1c) in two groups were recorded to assess the curative effect. Results Results of this study showed the overall rate of effectiveness in study group was statistically higher than that in control group(P<0.05). The status of indicators in patients of both two groups improved whereas the status in study group improved more than control group(P<0.05). Conclusion Treatment combining insulin glargine and repaglinide in patients with type-2 diabetes could improve the curative effect, relive clinical symptoms and control the levels of blood glucose indicators. The curative effect was good and this treatment was worth clinical promotion.
[Key words] Insulin glargine; Repaglinide; Type-2 diabetes
2型糖尿病又被稱作為成人發(fā)病型糖尿病[1]。35~40歲人群為2型糖尿病的高發(fā)人群,90%的2型糖尿病患者均在35~40歲發(fā)病[2]。2型糖尿病患者并非產(chǎn)生胰島素的功能完全消失,部分患者甚至會出現(xiàn)胰島素產(chǎn)生過多的狀況[3]。導致患者血糖升高的主要原因為胰島素的作用、效果較差,所以需要對患者進行胰島素分泌刺激,以保證患者的胰島素供應[4]。部分患者甚至需要采用胰島素對其進行治療。
1資料與方法
1.1一般資料
選擇2016年3月~2017年6月間我院收治的2型糖尿病患者72例作為研究對象,按照電腦隨機數(shù)分組的方案,將其隨機分為兩組,分別為對照組和實驗組,每組36例患者。對照組男19例,女17例,年齡37~62歲,平均(45.9±8.1)歲;實驗組男18例,女18例,年齡34~62歲,平均(46.1±8.4)歲。兩組患者一般資料比較差異無統(tǒng)計學意義(P>0.05),具有可比性。
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