甲巰咪唑與糖皮質(zhì)激素聯(lián)合治療甲狀腺功能亢進(jìn)癥合并癥的效果分析

　　摘   要：目的  分析甲巰咪唑與糖皮質(zhì)激素聯(lián)合治療甲狀腺功能亢進(jìn)癥合并癥的臨床效果。方法  收集我院2016年3月～2017年3月收治的130例甲狀腺功能亢進(jìn)癥合并癥患者作為研究對(duì)象，隨機(jī)分為A組和B組，每組65例，A組采用甲巰咪唑治療，B組采用甲巰咪唑與糖皮質(zhì)激素聯(lián)合治療。對(duì)比兩組患者臨床療效以及肝功能情況。結(jié)果  B組患者治療總有效率53.85%高于A組患者的35.38%， 差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后兩組患者丙氨酸氮基轉(zhuǎn)氨酶和天門(mén)冬氨酸基轉(zhuǎn)氨低于治療前，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。B組患者治療后丙氨酸氮基轉(zhuǎn)氨酶和天門(mén)冬氨酸基轉(zhuǎn)氨低于A組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論  甲巰咪唑與糖皮質(zhì)激素聯(lián)合治療甲狀腺功能亢進(jìn)癥合并癥效果良好，能促進(jìn)患者肝功能改善，加速患者恢復(fù)，因此可進(jìn)行臨床推廣應(yīng)用。
　　關(guān)鍵詞：甲狀腺功能亢進(jìn)癥合并癥;甲巰咪唑;糖皮質(zhì)激素
　　中圖分類(lèi)號(hào)：R581.1                                  文獻(xiàn)標(biāo)識(shí)碼：A                                DOI：10.3969/j.issn.1006-1959.2018.05.048
　　文章編號(hào)：1006-1959（2018）05-0136-02
　　Analysis of Effects of Methimazole and Glucocorticoids on Complications of Hyperthyroidism
　　MIAO Yan-ru
　�。―epartment of Endocrinology，Suizhong County Hospital，Suizhong 125200，Liaoning，China）
　　Abstract：Objective  To analyze the clinical effect of methimazole and glucocorticoids in the treatment of hyperthyroidism complications.Methods  A total of 130 cases of hyperthyroidism comorbidities treated in our hospital from March 2016 to March 2017 were collected and randomly divided into group A and group B，with 65 cases in each group.Group A was treated with methimazole. Group B was treated with methimazole and glucocorticoids.The clinical efficacy and liver function of the two groups were compared. Results  The total effective rate of treatment in group B was 53.85%，which was higher than that in group A 35.38%，the difference was statistically significant（P<0.05）.After treatment，alanine aminotransferase and aspartate aminotransferase were lower than before treatment in the two groups，the difference was statistically significant（P<0.05）.Group B of patients after treatment of alanine aminotransferase and aspartate amino transaminase is lower than the group A，the difference was statistically significant（P<0.05）. Conclusion  Methimazole combined with glucocorticoids in the treatment of hyperthyroidism complications with good effect，can promote liver function improvement，accelerate the recovery of patients，it can be carried out in clinical application.
　　Key words：Hyperthyroidism complication;Methimazole;Glucocorticoid
　　甲狀腺功能亢進(jìn)癥合并癥（hyperthyroidism complication）是一種比較常見(jiàn)的內(nèi)分泌系統(tǒng)疾病，這種疾病能夠?qū)�患者的消化系統(tǒng)以及造血系統(tǒng)造成比較大的傷害，目前臨床治療主要采用甲巰咪唑和丙巰氧嘧啶，或聯(lián)合倍他樂(lè)克等β受體阻滯劑治療。有研究表明[1]，單純應(yīng)用抗甲狀腺藥物治愈率只有50%，且會(huì)造成患者白細(xì)泡降低，肝功能受損等不良反應(yīng)發(fā)生，基于此，現(xiàn)對(duì)綏中縣醫(yī)院內(nèi)分泌科2016年3月～2017年3月收治的130例甲狀腺功能亢進(jìn)癥合并癥患者，進(jìn)行甲巰咪唑與糖皮質(zhì)激素聯(lián)合治療對(duì)臨床效果及肝功能損害，現(xiàn)總結(jié)如下。

相關(guān)熱詞搜索：咪唑 合并癥 激素 效果 治療