Gab2在宮頸癌組織中的表達(dá)及臨床意義

　　[摘要]目的 探討Gab2在宮頸癌組織中的表達(dá)情況與臨床病理特征的相關(guān)性。方法 隨機(jī)選取遵義醫(yī)學(xué)院附屬醫(yī)院病理科保存的2012年1月～2013年12月經(jīng)病理確診的80例宮頸癌組織標(biāo)本及20例正常宮頸組織標(biāo)本，分別采用免疫組織化學(xué)實(shí)驗(yàn)方法檢測(cè)Gab2在宮頸癌組織及正常宮頸組織中的表達(dá)情況，并結(jié)合臨床病理資料進(jìn)行統(tǒng)計(jì)分析。結(jié)果 Gab2蛋白在80例宮頸癌組織中的陽(yáng)性表達(dá)率為58.75%（47/80），而在20例正常宮頸組織中僅3例呈弱陽(yáng)性表達(dá)，陽(yáng)性表達(dá)率為0.00%，兩組結(jié)果比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。在宮頸癌組織中，Gab2蛋白的表達(dá)水平與淋巴結(jié)轉(zhuǎn)移呈正相關(guān)（P<0.05），與年齡、腫瘤大小、組織學(xué)分級(jí)及FIGO分期無(wú)顯著相關(guān)性（P>0.05）。Gab2高表達(dá)患者的復(fù)發(fā)轉(zhuǎn)移率顯著高于Gab2低表達(dá)患者（P=0.001）。結(jié)論 Gab2可能在宮頸癌發(fā)生和進(jìn)展中起著重要作用，可能具有作為宮頸癌預(yù)后判斷標(biāo)志物的潛能。
　　[關(guān)鍵詞]宮頸癌；Gab2；免疫組織化學(xué)；淋巴結(jié)轉(zhuǎn)移
　　[中圖分類號(hào)] R737.33 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721（2018）2（b）-0008-03
　　Expression and clinical significance of Gab2 in cervical cancer tissue
　　ZHANG Yan CHENG Long DUAN Wen-li LIU Xiao ZHOU Hang
　　Department of Abdominal Oncology，Affiliated Hospital of Zunyi Medical College，Guizhou Province，Zunyi 563000，China
　　[Abstract]Objective To investigate the correlation between the expression of Gab2 in cervical cancer tissue and the clinical pathological features.Methods 80 cervical cancer specimens definitely diagnosed by pathology from January 2012 to December 2013 and 20 normal cervical tissue specimens which were stored in our Department of Pathology were randomly selected in our hospital.The immunohistochemical method was used to detect the expression of Gab2 in cervical cancer tissues and normal cervical tissues，and was statistically analyzed together with the clinical and pathological data.Results The positive expression rate of Gab2 in 80 cervical cancer tissues was 58.75% （47/80），and in the 20 normal cervical tissues，only 3 cases were presented with weak positive expression.The rate of positive expression was 0%，which was displayed a statistical difference （P<0.05）.The expression level of Gab2 protein in cervical cancer tissues was positively correlated with lymph node metastasis （P<0.05），but didn’t present with great correlation with age，size of tumor，histological grading or FIGO stage （P>0.05）.The recurrence and metastasis rate in patients with high Gab2 expression was significantly higher than that of low expression of Gab2 （P=0.001）.Conclusion Gab2 may play an important role in the occurrence and progression of cervical cancer，and may be considered as a potential for prognostic marker of cervical cancer.
　　[Key words]Cervical cancer；Gab2；Immunohistochemistry；Lymph node metastasis
　　宮頸癌（cervical cancer，CC）在我國(guó)女性生殖道惡性腫瘤中發(fā)病率位居第一[1]，淋巴結(jié)轉(zhuǎn)移發(fā)生率高、局部復(fù)發(fā)和遠(yuǎn)處轉(zhuǎn)移是治療失敗的主要原因，嚴(yán)重影響著女性的身心健康。Gab2（Grb2-associated binding protein 2，Gab2）屬于Gabs蛋白家族（Grb2-associated binder family proteins）的多位點(diǎn)銜接蛋白[2]，具有潛在的原癌基因特性，在多種惡性腫瘤的發(fā)生、發(fā)展中有著重要作用，如在肺癌、乳腺癌及結(jié)直腸癌等腫瘤中顯著表達(dá)[3-5]。然而，有關(guān)Gab2蛋白在宮頸癌中的表達(dá)模式和臨床意義尚不清楚。本實(shí)驗(yàn)通過(guò)免疫組織化學(xué)法檢測(cè)Gab2在宮頸癌及正常宮頸組織中的表達(dá)水平及其與臨床病理特征的關(guān)系，評(píng)估Gab2在宮頸癌預(yù)后判斷標(biāo)志物的潛在臨床價(jià)值，現(xiàn)報(bào)道如下。

相關(guān)熱詞搜索：宮頸癌 表達(dá) 組織 臨床意義 Gab2